Shcherbak M.O., Kaplaushenko A.G.. The Study Of Acid-base Properties Of 2-(4-amino-5-(2-, 3-, 4-nitrophenyl)-1,2,4-triazole-3-ylthio) Acetic Acids And Their Salts


Natural Sciences / Chemistry / Pharmacy

Submitted on: Feb 19, 2014, 01:49:59

Description: The creation of new original drugs is one of the major aims of pharmaceutical industry for today, it based on purposeful synthesis of new highly efficient and low-toxic compounds and the study of its biological activity. From both practical and theoretical point of view the determination of ionization constants of synthesized compounds plays an important role. In our work we determined ionization constants of 2-(4-amino-5-(2-nitrophenyl)-1,2,4-triazole-3-ylthio)acetic acids and its salts and detected the influence of substituents on the acid-base properties of the compounds. Suggestion that discussed acids and their salts in oral administration will be more actively absorbed in the stomach or bowels has been made based on the results.

The abstract of this article will be published in the February 2014 issue of "Intellectual Archive Bulletin", ISSN 1929-1329.

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Shcherbak.doc



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